Topic Overview: MacDonald and colleagues observed robust changes to phosphorylation levels of canonical postsynaptic proteins in Sz. WGCNA and cross-network analyses observed significant correlations among synaptosome, phosphorylation, and dendritic spine alterations in Sz. Phosphorylation sites on eight proteins were highly correlated with both synaptic protein alterations and spine loss. Of these eight proteins, all but one have well-documented roles in vesicular trafficking of postsynaptic glutamate receptors and/or regulating dendritic spines. When modeled in mice, one of these candidate phosphorylations (MAP2 S426E) decreased cortical dendritic spines numbers, further supporting a causal role for these phosphorylations in Sz pathology. Continuing Medical Education (CME) credit: To receive CME credit for this lecture, text the code CADHUM to 412-312-4424 within 24 hours of the session’s start. (Your mobile phone number first must be linked to your account at cce.upmc.com.) You can also email kbg12@pitt.edu to receive credit for this session. Click here for more information about CME.
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